data thread: what exactly does GLP-1 do per the current trials

read the STEP and SURMOUNT trials + extensions. short version: ~15-20% body weight loss at peak on semaglutide / tirzepatide respectively. weight regain is common after stopping, less so if behavior changes stick. cardiovascular benefits appear real. side effects are real too. these are powerful tools used badly in a lot of places. curious what others with >12 months on therapy are seeing.