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the 4 supplements i'd actually defend buying

278💬 47· @derek_labrat

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@derek_labrat·4/13/2026

the 4 supplements i'd actually defend buying

after years of trying 20+ things, the ones i always come back to: - creatine monohydrate (5g, muscle + cognition) - vitamin D (if your levels are low, confirm with labs) - magnesium glycinate at night (sleep + muscle) - omega-3 fish oil (if you don't eat fatty fish 2x/wk) everything else was situational or didn't move my bloodwork. save your money.

278💬 47👁 556
@sage_rising·4/7/2026

magnesium glycinate vs citrate vs l-threonate - my n=1

rotated each for 4 weeks: - citrate: pooped on time every day, didn't feel different otherwise - glycinate: slept deeper, woke less during the night - l-threonate: maybe slightly clearer head in the morning? subjective. glycinate won for me. but honestly magnesium in any form seems to do something useful if you're deficient.

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@ash_tries_stuff·4/1/2026

ashwagandha made me feel weirdly flat, anyone else?

took KSM-66 600mg daily for 6 weeks. stress went down. also my motivation went down. felt emotionally muted, not in a good way. stopped it, came back within a week. not all adaptogens are for all people. how did it go for you?

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@benny_lifts·4/4/2026

creatine HCL vs monohydrate - the HCL premium is a scam

tried HCL for 3 months because of the 'less bloating' hype. went back to good old mono. my gains and recovery were identical and HCL costs like 4x. if you bloat on mono try a smaller dose more often, don't pay extra for a fancier label.

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@tom_skeptic·3/27/2026

stop buying multivitamins, a thread

most multis are under-dosed on the things you actually need and over-dosed on stuff you don't. you're better off identifying the 1-3 things your bloodwork actually shows low and supplementing those specifically. i cut my supplement cabinet from 11 bottles to 3 and feel exactly the same.

201💬 38👁 795

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@sara_foodie·3/24/2026

the case for getting most of it from food

boring advice but here we go. i tried to optimize with capsules for years. when i just ate an actual varied diet with fatty fish twice a week, leafy greens daily, enough red meat for iron, legumes, fruit — most of my marker improvements happened there. supplements fill gaps. they're not the main show. my pantry is cheaper and my gut is happier.

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@jenny_again·3/18/2026

peri supplement stack — what i landed on after a year

for me at 48: - magnesium glycinate nightly - omega-3 - vitamin D3 + K2 (D was 22 on my labs) - b-complex (doc suggested after a fatigue workup) - creatine (started for strength, kept for the cognitive boost) things i tried and dropped: ashwagandha, maca, evening primrose oil (subjective nothing for me). HRT is doing the heavy lifting honestly, supplements are supporting cast.

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@nina_reads_labels·3/22/2026

read the back of your vitamin D bottle carefully

D3 absorbs way better than D2. and both need fat to absorb properly. taking a dry D capsule with a bowl of cereal is kind of a waste. take it with eggs or olive oil or a meal with some fat in it. also check the cofactors — D loves to be taken with K2 if you're going high dose.

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@ryan_chronic·3/6/2026

LDN for hashimotos + fatigue — 6 month check in

low dose naltrexone 4.5mg at bedtime prescribed off-label for autoimmune. the first month my sleep was weird (vivid dreams). by month 3 my fatigue was the lowest it had been in years. not a miracle. maybe 30-40% better. brain fog is the big one that lifted. not a supplement technically but adjacent. worth asking your doc about if you're in autoimmune world.

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@kai_19·3/14/2026

zinc for acne - did it do anything?

15mg zinc picolinate daily for 3 months during my pre-accutane era. slight improvement in breakouts maybe? hard to say. kept it going as a 'just in case' because it's cheap. don't go over 40mg/day without labs, can mess with copper.

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